Chemical logic of MraY inhibition by antibacterial nucleoside natural products

Muraymycin nucleoside-peptide antibiotics: uridine-derived natural products as lead structures for the development of novel antibacterial agents

Muraymycins are a promising class of antimicrobial natural products. These uridine-derived nucleoside-peptide antibiotics inhibit the bacterial membrane protein translocase I (MraY), a key enzyme in the intracellular part of peptidoglycan biosynthesis. This review describes the structures of naturally occurring muraymycins, their mode of action, synthetic access to muraymycins and their analogu...

Chemical Synthesis of Nucleoside Analogues Chemical Synthesis of Nucleoside Analogues

Screening Methods to Determine Antibacterial Activity of Natural Products

The emergence of new infectious diseases, the resurgence of several infections that appeared to have been controlled and the increase in bacterial resistance have created the necessity for studies directed towards the development of new antimicrobials. Considering the failure to acquire new molecules with antimicrobial properties from microorganisms, the optimization for screening methods used ...

Title : Comparisons Between Chemical Vs . Natural Antibacterial Agents

I. Abstract: Our group was interested in exploring whether or not the natural antibacterial agents garlic, lemon juice, and tea tree oil worked just as well if not better than chemically man-made antibacterial agents. By preparing an Echericia Coli (E. coli) bacteria culture and following Antiseptic and Plating Technique we prepared petri dishes, viewed the results 24 hours later, and made the ...

Synthesis of gem-difluorinated nucleoside analogues of the liposidomycins and evaluation as MraY inhibitors.

Two gem-difluoromethylenated nucleoside moieties of liposidomycins, 3 and 4, were designed and synthesized. Compound 3 was assembled from lactol 5 and gem-difluoromethylenated nucleoside 6. In the synthesis of target molecule 4, the coupling of the trichloroacetimidate derivative of gem-difluoromethylenated furanose 7 with nucleoside 8 in the presence of TMSOTf gave the unexpected compound 16 w...